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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Oliver Methfessel<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Leitung IT<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Aukamm-Apotheke<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext"> AUMEAS Gruppe<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Ltd. Apotheker Martin Hofmann e.K.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Kloppenheimer Weg 11, 65191 Wiesbaden<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Tel : 0611 95016 122<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Fax : 0611 95016 195<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext">Amtsgericht Wiesbaden HRA 4521<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext"><a href="http://www.aumeas.de/"><span style="color:#0563C1">http://www.aumeas.de</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New";color:windowtext"><a href="mailto:o.methfessel@aumeas.de"><span style="color:#0563C1">o.methfessel@aumeas.de</span></a><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="color:windowtext">Von:</span></b><span style="color:windowtext"> CSL Seqirus <ccc@seqirus.com>
<br>
<b>Gesendet:</b> Dienstag, 19. November 2024 08:39<br>
<b>An:</b> AUMEAS Wiesbaden <mail@aumeas.de><br>
<b>Betreff:</b> Update STIKO Empfehlung<o:p></o:p></span></p>
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<p align="center" style="text-align:center"><span style="font-size:10.5pt;font-family:"Montserrat Light"">Stefan-George-Ring 23, 81929 München</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#EE262A">CSL.com </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p align="right" style="margin-right:-6.5pt;text-align:right"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#EE262A">CSLSeqirus.com </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><strong><span style="font-size:12.0pt;font-family:Montserrat">Fluad<sup>®</sup> Tetra </span></strong><span style="font-size:12.0pt;font-family:Montserrat">von CSL Seqirus ist der<strong><span style="font-family:Montserrat">
einzige MF59<sup>®</sup></span></strong> <strong><span style="font-family:Montserrat">adjuvantierte Influenza-Impfstoff, </span></strong>mit</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
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<li class="MsoNormal" style="mso-list:l0 level1 lfo1"><strong><span style="font-size:12.0pt;font-family:Montserrat">Wirkverstärkung durch ein natürliches Adjuvans</span></strong><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l0 level1 lfo1"><strong><span style="font-size:12.0pt;font-family:Montserrat">Guter Verträglichkeit </span></strong><span style="font-size:12.0pt;font-family:Montserrat">und</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l0 level1 lfo1"><strong><span style="font-size:12.0pt;font-family:Montserrat">Wirtschaftlichem Preis.</span></strong><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></li></ul>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-add-space:auto">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:Montserrat">was den Impfstoff zu einer
<strong><span style="font-family:Montserrat">smarten</span></strong> Wahl für die
<strong><span style="font-family:Montserrat">kommende Grippesaison</span></strong> macht.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:Montserrat">Fluad<sup>®</sup> Tetra ist bereits
<strong><span style="font-family:Montserrat">ab 50 Jahren zugelassen</span></strong>.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:Montserrat">Die Veröffentlichung der Empfehlung zu diesem Zeitpunkt soll sicherstellen, dass diese<strong><span style="font-family:Montserrat"> </span></strong>bereits
für die <strong><span style="font-family:Montserrat">Vorbestellung der Grippeimpfstoffe</span></strong> für die
<strong><span style="font-family:Montserrat">Saison 2025/26 rechtzeitig berücksichtigt</span></strong> werden kann.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:Montserrat">Weitere Infos zur STIKO-Empfehlung und rund um Fluad<sup>®</sup> Tetra finden Sie </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><a href="https://a529x.r.ag.d.sendibm3.com/mk/cl/f/sh/SMK1E8tHeFuBlCiaBg9EPOYZWz7V/9OzkaXTkBrHj" target="_blank"><strong><span style="font-family:Montserrat">hier</span></strong></a></span><span style="font-size:12.0pt;font-family:Montserrat">.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:Montserrat">Es wurden bereits
<strong><span style="font-family:Montserrat">über 500 Millionen Dosen des adjuvantierten Grippeimpfstoffs</span></strong> weltweit verteilt.
<strong><span style="font-family:Montserrat">CSL Seqirus</span></strong> ist Ihr verlässlicher Partner, mit
<strong><span style="font-family:Montserrat">zuverlässiger</span></strong> und<strong><span style="font-family:Montserrat"> pünktlicher Lieferung.</span></strong>* </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-line-height-alt:0pt"><a href="https://a529x.r.ag.d.sendibm3.com/mk/cl/f/sh/SMK1E8tHeG13DLXXMqIiVDrJVHhl/eY5sLjMl1Mu0" target="_blank"><span style="font-size:1.0pt;text-decoration:none"><img border="0" width="306" height="57" style="width:3.1875in;height:.5937in" id="_x0000_i1026" src="https://a529x.img.ag.d.sendibm3.com/im/sh/Q4xiwVBSum6c.png?u=7xwQLFBtniwQnLwU0PX4Lsj7Ej0sgvF"></span></a><span style="font-size:1.0pt"><o:p></o:p></span></p>
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<p><span style="font-size:12.0pt;font-family:Montserrat">Mit freundlichen Grüßen</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p><span style="font-size:12.0pt;font-family:Montserrat">Ihr CSL Seqirus Team</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><a name="_Hlk180427749"><u><span style="font-size:7.0pt;font-family:"Montserrat Light";color:#EE262A">1. </span></u></a><span style="font-size:7.0pt;font-family:"Montserrat Light"">RKI, Epidemiologisches
Bulletin 44/2024, 31. Oktober 2024.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><br>
</span><span style="font-size:7.0pt;font-family:"Montserrat Light"">* CSL Seqirus wird der STIKO Empfehlung folgen und in der Saison 2025/26 trivalente Formulierungen ausliefern. Dosen seit Einführung (saisonal und pandemisch).</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="text-align:justify"><strong><span style="font-size:7.0pt;font-family:"Montserrat Light";color:black">Fluad Tetra - Injektionssuspension in einer Fertigspritze</span></strong><span style="font-size:7.0pt;font-family:"Montserrat Light";color:black">. </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="text-align:justify"><strong><span style="font-size:7.0pt;font-family:"Montserrat Light";color:black">Wirkstoff:</span></strong><span style="font-size:7.0pt;font-family:"Montserrat Light";color:black"> Influenza-Impfstoff (Oberflächenantigen, inaktiviert,
adjuvantiert).</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p style="text-align:justify"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p><span style="font-size:7.0pt;font-family:"Montserrat Light"">Dieses Arzneimittel unterliegt einer zusätzlichen Überwachung. Dies ermöglicht eine schnelle Identifizierung neuer Erkenntnisse über die Sicherheit. Angehörige von Gesundheitsberufen sind aufgefordert,
jeden Verdachtsfall einer Nebenwirkung zu melden.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><br>
<o:p></o:p></span></p>
<p><strong><span style="font-size:7.0pt;font-family:"Montserrat Light"">Zusammensetzung: </span></strong><span style="font-size:7.0pt;font-family:"Montserrat Light"">Arzneil. wirks. Bestandt.: je 15 μg Hämagglutinin von verschiedenen Influenza-Virusstämmen
(Influenzavirus-Oberflächenantigen (Hämagglutinin und Neuraminidase), inaktiviert, in befruchteten Hühnereiern vermehrt) mit MF59C.1 als Adjuvans, entsprechend den jeweils aktuellen Empfehlungen der WHO (nördliche Hemisphäre) und der EU.
<strong><span style="font-family:"Montserrat Light"">Sonst. Bestandteile:</span></strong>
<u>Adjuvans</u> MF59C.1: Squalen (9,75 mg), Polysorbat 80 (1,175 mg), Sorbitantrioleat (1,175 mg), Natriumcitrat (0,66 mg) und Citronensäure (0,04 mg).
<u>Andere Hilfsstoffe:</u> Natriumchlorid, Kaliumchlorid, Kaliumdihydrogenphosphat, Dinatriumphosphat-Dihydrat, Magnesiumchlorid-Hexahydrat, Calciumchlorid-Dihydrat, Wasser für Injektionszwecke.
<strong><span style="font-family:"Montserrat Light"">Anwendungsgebiet: </span></strong>Influenzaprophylaxe für Erwachsene im Alter von 50 Jahren und älter.
<strong><span style="font-family:"Montserrat Light"">Gegenanzeigen: </span></strong>Überempfindlichkeit gegen die Wirkstoffe, gegen einen der Bestandteile des Adjuvans, einen der sonstigen Bestandteile oder gegen mögliche Rückstandsspuren wie z. B. Ovalbumin,
Kanamycin und Neomycinsulfat, Formaldehyd, Cetyltrimethylammoniumbromid (CTAB) und Hydrocortison. Schwere allergische Reaktion (z. B. Anaphylaxie) auf vorangegangene Influenza-Impfungen.
<strong><span style="font-family:"Montserrat Light"">Warnhinweise:</span></strong> Im Kühlschrank lagern. Nicht einfrieren. Spritze im Umkarton aufbewahren, um Inhalt vor Licht zu schützen.<strong><span style="font-family:"Montserrat Light""> Nebenwirkungen:</span></strong>
Kopfschmerzen, Myalgie, Arthralgie, Schmerzen an der Injektionsstelle, Ermüdung, Appetitverlust, Übelkeit, Diarrhö, Ekchymosen (oder blaue Flecken an der Injektionsstelle), Schüttelfrost, Erythem, Induration, grippeähnliche Erkrankung, Fieber (≥ 38°C), Lymphadenopathie,<i> </i>Erbrechen;
Thrombozytopenie (einige sehr seltene, schwere Fälle mit einer Thrombozytenzahl von weniger als 5.000 pro mm<sup>3</sup>), Allergische Reaktionen einschließlich anaphylaktischer Schock (in seltenen Fällen), Anaphylaxie, Enzephalomyelitis, Guillain-Barré-Syndrom,
Krämpfe, Neuritis, Neuralgie, Parästhesie, Synkope, Präsynkope, Vaskulitis, die möglicherweise mit vorübergehender Nierenbeteiligung assoziiert ist, Generalisierte Hautreaktionen einschließlich Erythema multiforme, Erythem, Urtikaria, Pruritus oder unspezifischer
Ausschlag, Angioödem, Muskelschwäche, Schmerz in einer Extremität, Ausgeprägte Schwellungen an der geimpften Extremität über eine Dauer von mehr als einer Woche, Cellulitis-ähnliche Reaktion an der Injektionsstelle, Asthenie, Unwohlsein, Fieber.
<strong><span style="font-family:"Montserrat Light"">Verschreibungspflichtig. Pharmazeutischer Unternehmer:</span></strong> Seqirus Netherlands B.V., Paasheuvelweg 28, 1105 BJ Amsterdam, Niederlande.<strong><span style="font-family:"Montserrat Light"">
</span></strong></span><a name="_Hlk172116991"><strong><u><span style="font-size:7.0pt;font-family:"Montserrat Light";color:#EE262A">Lokaler Ansprechpartner</span></u></strong></a><span style="font-size:7.0pt;font-family:"Montserrat Light"">: Seqirus GmbH,
Stefan-George-Ring 23, 81929 München, Deutschland, Telefon: 0800 3601010<strong><span style="font-family:"Montserrat Light"">Stand:</span></strong> Juli 2024</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
<p><span style="font-size:7.0pt;font-family:"Montserrat Light"">DEU-FLUT-24-0025</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p align="center" style="text-align:center"><strong><span style="font-size:13.5pt;font-family:"Arial",sans-serif">CSL Seqirus</span></strong><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<span style="font-size:10.5pt;font-family:"Arial",sans-serif">Seqirus GmbH, Stefan-George-Ring 23, 81929 München, Deutschland / Germany</span><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p align="center" style="text-align:center;text-decoration-style: initial;text-decoration-thickness: initial">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif">T: 0800 3601010 - Germany only| F: 0800 3601011 - Germany only | E: </span><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><a href="mailto:ccc@seqirus.com"><span style="font-size:10.5pt">ccc@seqirus.com</span></a><o:p></o:p></span></p>
<p align="center" style="text-align:center;text-decoration-style: initial;text-decoration-thickness: initial">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif">Geschäftsführer: Deborah Di Salvo | James Smith</span><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p align="center" style="text-align:center;text-decoration-style: initial;text-decoration-thickness: initial">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif">Sitz der Gesellschaft: München Handelsregister: München Nr. HRB
</span><span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#2A312D">295267</span><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<span style="font-size:10.5pt;font-family:"Arial",sans-serif">Burkhardt AG | Konto: 14563008 |IBAN: DE 12 3003 0880 0014 5630 08</span><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p align="center" style="text-align:center;text-decoration-style: initial;text-decoration-thickness: initial">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif">Swift Code: TUBDDEDDXXX | USt.ID.: DE154558251</span><span style="font-size:13.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p align="center" style="text-align:center"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><a href="https://a529x.r.ag.d.sendibm3.com/mk/un/sh/SMJz09a0vkbXpHcstuCuQhpS9fa1/QE3XUfX2GruS" target="_blank">Abbestellen</a><o:p></o:p></span></p>
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